A split (mid)brain for dopamine
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چکیده
منابع مشابه
A Split (mid)brain for Dopamine
mitter that has a role in movement and many aspects of cognition. Lammel et al. have now characterized two types of neurons in the mesocorticolimbic dopamine system that are not only anatomically segregated, with non-overlapping axonal target regions, but that also have distinct molecular and functional properties. This structured diversity of the dopamine midbrain system might contribute to th...
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Our sense of time is far from constant. For instance, time flies when we are having fun, and it slows to a trickle when we are bored. Midbrain dopamine neurons have been implicated in variable time estimation. However, a direct link between signals carried by dopamine neurons and temporal judgments is lacking. We measured and manipulated the activity of dopamine neurons as mice judged the durat...
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Receptors that couple to phosphoinositide hydrolysis, which include metabotropic glutamate receptors (mGluRs) and muscarinic receptors, are known to either activate or inhibit the activity of dopamine cells depending on the pattern of receptor activation. Transient activation of alpha1 adrenoceptors with norepinephrine (NE) resulted in an outward current in midbrain dopamine neurons recorded in...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2008
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2381